The rheumatoid arthritis diagnosis Diaries


In the world, more and more and more people are suffering from the failure of their immune systems to differentiate between healthy cells or invading microorganisms. Their organs and tissue are now being attacked by defenses against disease that they once had.




This trend is being tackled by large international research efforts. One example of this initiative is the London's Francis Crick Institute. Two world experts, James Lee (from the Americas) and Carola Vinuesa (from Italy), have established separate research groups to pinpoint the exact causes.


Lee told the Observer how the number of cases of autoimmune disease has increased in the past 40 years, particularly in Western countries. We now see some cases in countries where we had never had such illnesses before.


The Middle East, East Asia and Africa have seen the highest increase in the number of cases of inflammatory bowel disorders over the last few years. The patients had never previously had the disease before.


Autoimmune disorders range from type 1 diabetes to rheumatoid arthritis inflammatory bowel disease and multiple sclerosis. Each case is different. In every case, the immune system crosses its wires, and it switches to healthy tissue rather than infective agents.


Around 4 million people in the UK have suffered from these ailments. Others may suffer more than one. It is widely believed that the number of cases of autoimmune disease is increasing by between 3 and 9 percent each year. The reason for this is believed to be due to environmental factors, according most researchers.


Lee, who was formerly located at Cambridge University, stated that our genetic makeup has not changed in the last few decades. Something is going on outside that's increasing the risk of developing autoimmune disease.


This notion was endorsed by Vinuesa, who was previously located at the Australian National University. She cited changes in the diet occurring as more and more nations adopted western-style eating habits and people bought more fast food.


Vinuesa said that some vital components of fast food diets aren't present which includes fiber. It is known to suggest that altering a person’s microbiome (the collection of microorganisms we are able to digest) could result in the loss of certain bodily functions.


These changes in our microbiomes can trigger the development of autoimmune diseases, of which more than 100 have been diagnosed.


Both researchers emphasized that individual susceptibilities were involved in contracting such illnesses, ailments that also include celiac disease as with lupus, which causes swelling and inflammation, and may cause damage to different organs, such as the heart.


Vinuesa said "If you don't have a genetic predisposition to autoimmune disorders it is unlikely that you will develop one, no matter how many Big Macs you eat." "We are unable to slow the growth of fast-food restaurants all over the world. Instead, we're focused on the genetic elements which cause autoimmune illnesses. We are trying to understand why some people are more susceptible than others. This is the method we are using to address the problem."


Because of the advancement of technology, researchers are now capable of identifying tiny differences between individuals' DNA. It is possible to identify the common genetic patterns that are common to those who suffer from an autoimmune condition.


Lee said that we did not have the equipment to sequence DNA prior to. However, now we have the capability to sequence DNA on large scales, which has had a profound impact in our lives. Inflammatory bowel diseases were only Click here one of the Check out variants that we could identify at the time I started my study. Today, we have more than 250.


This is at the core of Lee's and Vinuesa’s work. They aim to discover how different genetic pathways function and to discover the different kinds of diseases that researchers are currently studying. Vinuesa said there could be many versions of some conditions that cause autoimmune disease, such as Lupus. It is crucial to recognize the implications of this when trying to find the correct treatment.


There are numerous beneficial new treatments in the pipeline, we don't yet know what people they ought to be offered to. This is because we aren't able to pinpoint the precise nature of their disease. And that is now a key goal for autoimmune research. To determine the most effective treatment, it is necessary to understand how to classify and categorize patients.


Lee stated that the growing incidence of autoimmune diseases around the globe meant that new drugs and treatments were urgently required. There is currently no treatment for autoimmune disease that are most often seen in teens, who are trying to land their first job, finish school, and take care of their families.


It means that a growing number of people will need undergo surgery or receive regular injections. It's a very stressful experience for patients as well as an enormous strain on health care system. We require innovative and effective treatment methods.


Rheumatoid is an auto-immune condition. This means that the immune system is attacking healthy tissue. But it isn't yet clear what triggers it.


The immune system usually produces antibodies that fight against bacteria and viruses, helping to fight infections.


If you suffer from rheumatoid disease the immune system sends antibodies towards the joint's lining and attack the surrounding tissue.


The thin, cell-like layer that covers your joints (synovium) to get inflamed and sore and releases chemicals that can cause harm to the area.


bones

Cartilage is the connective tissue between bones.

Tendons are the connective tissue that connects bone to muscle.

Ligaments - The ligaments - The tissue that connects cartilage to bone

Rheumatoid arthritis can be treated but not treated. The chemicals can cause joints to become unbalanced and distorted. The final result may be irreparable.


There are many theories about how the immune system can attack the joints have been suggested for example, an infection as a trigger, but none of them has been confirmed.


Possible risk factors



There are many factors that increase the risk of developing rheumatoid, such as:


Your genes - There's some evidence suggesting that Rheumatoid arthritis is passed down through families. But the chance of it being passed on to a child is very low as genes play an insignificant influence on the condition.

hormones. Rheumatoid arthritis is more common in women than men, which could be due to effects of the hormone estrogen, however, this connection hasn't been proven

Smoking is a major risk factor for rheumatoid arthritis. Some evidence supports this.

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